Visit https://www.sheffield.ac.uk/mbb/postgraduate/phd/projects for more information on research projects in Molecular Biology and Biotechnology at the University of Sheffield.
Further opportunities detailed below:
To kill and cure: Understanding antibiotic action to enhance activityMRC DiMeN Doctoral Training Partnership: Funded PhD Opportunity
Antibiotics are at the core of modern medicine, but they are under threat due to the spread of resistance. Antibiotics either kill (bactericidal) or stop bacteria growing (bacteriostatic). Extraordinarily we still do not know why only some antibiotics kill or what mechanism(s) lead to death. Such understanding will underpin the rational use of existing and aid in the design of novel interventions to reduce the burden of disease. Our recent research has begun to elucidate the principles underpinning bacterial growth and division (Nature, 2020), how these are compromised by antibiotics and how resistance circumvents this action (PLoS Pathogens, 2020). This has led to a new hypothesis whereby bactericidal antibiotics, such as penicillin, kill due to a dysregulation of cell wall homeostasis, in the absence of synthesis. The aim of the project is to take an interdisciplinary approach to unravel the fundamental mechanisms governing how antibiotics kill bacteria. For further details click here.
Assembly of a Bacterial Killing MachineMRC DiMeN Doctoral Training Partnership: Funded PhD Opportunity
This is a PhD opportunity at Newcastle University with Prof Tracy Palmer, co-supervised by Prof Simon Foster
Staphylococcus aureus is a major antibiotic-resistant bacterial pathogen of humans. Although frequently found as a human commensal, it can cause life-threatening diseases including pneumonia and necrotising fasciitis. To colonise the host, it must compete with the resident microbiota. The Palmer group have demonstrated that S. aureus uses a Type VII protein secretion system (T7SS) to secrete toxins that target other bacteria, important for establishing colonisation. The T7SS comprises six components that homo- and hetero-multimerise to form a large secretion machine which spans the cell wall to deliver proteins to the surface. This studentship will elucidate how the T7SS is functionally assembled in vivo. For further details click here.