19th January 2021
New publication :
The Role of Macrophages in Staphylococcus aureus Infection
In this review we examine macrophage-S. aureus interactions through early and late stages of infection. The important role of macrophages in controlling S. aureus infection is highlighted, including the mechanisms used to kill invading bacteria. We also discuss strategies used by S. aureus to evade or subvert macrophage functions to promote infections.
Pidwill, G. R., Gibson, J. F., Cole, J., Renshaw, S. A. & Foster, S. J. The Role of Macrophages in Staphylococcus aureus Infection. Front. Immunol. 11, 3506 (2021).
11th December 2020
F18's Virtual Xmas party
Had a great Christmas party with an awesome festive quiz from Bartek and Josh!
26th November 2020
New PhD Opportunity :
To kill and cure: Understanding antibiotic action to enhance activity
Antibiotics are at the core of modern medicine, but they are under threat due to the spread of resistance. Antibiotics either kill (bactericidal) or stop bacteria growing (bacteriostatic). Extraordinarily we still do not know why only some antibiotics kill or what mechanism(s) lead to death.
4th November 2020
Viva congratulations to Laia!
Massive congrats to Dr. Laia Pasquina-Lemonch on passing her viva!
The Foster lab are looking forward to continuing work together in the future
Evolution of Beta-Lactam resistance in MRSA
The model system constructed in this work mimics the naturally occurring MRSA, to understand the underpinning mechanisms of S. aureus which develop high-level resistance. Our study reveals a novel effect of mecA acquisition and compensatory mutations on central metabolism and sheds light on potential pathways essential for high-level resistance.
You can read our new Publication Evolution of Beta-lactam resistance in MRSA in PLOS Pathogens.
26th June 2020
Congratulations Dr. Sutton
A huge congratulations to Josh for passing his viva! Well deserved Prosecco in the park.
All of the Foster lab wish you the best of luck in the future!
The architecture of the Gram-positive bacterial cell wall
New research, published in Nature, revealed a new and unexpected structure of the outer bacterial layers of the bacterium Staphylococcus aureus. Click here to read
Scientists from the Hobbs and Foster Labs at the University of Sheffield have produced the first high-resolution images of the structure of the cell wall of bacteria using Atomic Force Microscopy (AFM), in a study that could further understanding of antimicrobial resistance.
The findings set a new framework for understanding how bacteria grow and how antibiotics work, overturning previous theories about the structure of the outer bacterial layers.
Simon's Virtual seminar
Simon delivered a talk titled Bacterial Cell Wall Architecture and Dynamics: A Matter of Life and Death as part of the virtual S.aureus seminar series.
F18 Christmas 2019
Awesome F18 Christmas social featuring
mince pies, a winter walk, dinner,
drinks and the Turkey hat!